U.S. surgeons successfully test pig kidney transplant in human patient

Started by drunkenshoe, October 20, 2021, 03:48:03 AM

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drunkenshoe

U.S. surgeons successfully test pig kidney transplant in human patient

It's pretty exciting.  :cheer: Dat's gonna change zsome things in zsooome placesss... :whistle:

QuoteNEW YORK, Oct 19 (Reuters) - For the first time, a pig kidney has been transplanted into a human without triggering immediate rejection by the recipient's immune system, a potentially major advance that could eventually help alleviate a dire shortage of human organs for transplant.

The procedure done at NYU Langone Health in New York City involved use of a pig whose genes had been altered so that its tissues no longer contained a molecule known to trigger almost immediate rejection.

The recipient was a brain-dead patient with signs of kidney dysfunction whose family consented to the experiment before she was due to be taken off of life support, researchers told Reuters.

For three days, the new kidney was attached to her blood vessels and maintained outside her body, giving researchers access to it.

Test results of the transplanted kidney's function "looked pretty normal," said transplant surgeon Dr. Robert Montgomery, who led the study.

The kidney made "the amount of urine that you would expect" from a transplanted human kidney, he said, and there was no evidence of the vigorous, early rejection seen when unmodified pig kidneys are transplanted into non-human primates.

The recipient's abnormal creatinine level - an indicator of poor kidney function - returned to normal after the transplant, Montgomery said.

In the United States, nearly 107,000 people are presently waiting for organ transplants, including more than 90,000 awaiting a kidney, according to the United Network for Organ Sharing. Wait times for a kidney average three-to-five years.

Researchers have been working for decades on the possibility of using animal organs for transplants, but have been stymied over how to prevent immediate rejection by the human body.

Montgomery's team theorized that knocking out the pig gene for a carbohydrate that triggers rejection - a sugar molecule, or glycan, called alpha-gal - would prevent the problem.

The genetically altered pig, dubbed GalSafe, was developed by United Therapeutics Corp's (UTHR.O) Revivicor unit. It was approved by the U.S. Food and Drug Administration in December 2020, for use as food for people with a meat allergy and as a potential source of human therapeutics.

Medical products developed from the pigs would still require specific FDA approval before being used in humans, the agency said.

Other researchers are considering whether GalSafe pigs can be sources of everything from heart valves to skin grafts for human patients.

The NYU kidney transplant experiment should pave the way for trials in patients with end-stage kidney failure, possibly in the next year or two, said Montgomery, himself a heart transplant recipient. Those trials might test the approach as a short-term solution for critically ill patients until a human kidney becomes available, or as a permanent graft.

The current experiment involved a single transplant, and the kidney was left in place for only three days, so any future trials are likely to uncover new barriers that will need to be overcome, Montgomery said. Participants would probably be patients with low odds of receiving a human kidney and a poor prognosis on dialysis.

"For a lot of those people, the mortality rate is as high as it is for some cancers, and we don't think twice about using new drugs and doing new trials (in cancer patients) when it might give them a couple of months more of life," Montgomery said.

The researchers worked with medical ethicists, legal and religious experts to vet the concept before asking a family for temporary access to a brain-dead patient, Montgomery said.

Reporting by Nancy Lapid; Editing by Michele Gershberg and Bill Berkrot
"I believe you find life such a problem because you think there are good people and bad people. You're wrong, of course. There are, always and only, the bad people, but some of them are on opposite sides." Havelock Vetinari

SGOS

Medical Science advances again.  This one is of particular interest to me, because I lost one kidney to cancer 25 years ago.  Not that I need a kidney right now.  The fact is you only need one, and there is absolutely no reason for two, other than to have one as a spare.  Right now I don't have a spare, and kidneys play a fairly important role in keeping you alive.

Shiranu

Quote from: SGOS on October 21, 2021, 07:10:01 AM
Medical Science advances again.  This one is of particular interest to me, because I lost one kidney to cancer 25 years ago.  Not that I need a kidney right now.  The fact is you only need one, and there is absolutely no reason for two, other than to have one as a spare.  Right now I don't have a spare, and kidneys play a fairly important role in keeping you alive.

Too bad we don't have a spare of every organ, although that would start to take up a lot of space.
Every day is a good day to *remove from server* an autocrat.

Dark Lightning

As one of those people with age-related kidney degradation (I hate to say failure, as they just don't function as well as they used to- they haven't failed per se) I'm liking the advances in medicine, and not just this with the kidneys.